Document 0154
 DOCN  M9490154
 TI    Cerebrospinal fluid p24 antigen levels and intrathecal immunoglobulin G
       synthesis are associated with cognitive disease severity in HIV-1.
 DT    9411
 AU    Singer EJ; Syndulko K; Fahy-Chandon BN; Shapshak P; Resnick L; Schmid P;
       Conrad AJ; Tourtellotte WW; Neurology Service, Veterans Affairs Medical
       Center West Los; Angeles, CA 90073.
 SO    AIDS. 1994 Feb;8(2):197-204. Unique Identifier : AIDSLINE MED/94318203
 AB    OBJECTIVE: To test the hypothesis that selected cerebrospinal fluid
       (CSF) markers [intrathecal immunoglobulin G (IgG) synthesis rate,
       oligoclonal IgG bands, and p24 antigen levels] are associated with the
       presence and severity of clinical HIV-1 neurologic disease. DESIGN AND
       METHODS: CSF and blood parameters from 142 HIV-seropositive subjects
       from the baseline examination of a longitudinal study were measured and
       analyzed in relationship with clinically derived cognitive impairment
       groups (none, mild, moderate) and with other neurologic and clinical
       classification groups. Subjects with opportunistic infections, lymphomas
       or neurosyphilis were excluded. RESULTS: The mean intrathecal IgG
       synthesis rate and mean CSF p24 antigen levels both differed
       significantly among cognitive impairment groups; more impairment was
       associated with a higher rate or level. Mean CSF p24 antigen levels were
       significantly higher in HIV-1-seropositive subjects with any HIV-1
       neurologic disease than in subjects without neurologic disease. In
       contrast, there were no significant differences among seropositive
       groups in any CSF parameter when stratified by systemic disease
       classification (asymptomatic HIV-seropositives, AIDS-related complex, or
       AIDS), independent of neurologic status. CONCLUSION: We conclude that
       there may be a relationship between the severity of HIV cognitive
       disease and increasing levels of intrathecal IgG synthesis and CSF p24
       antigen levels.
 DE    Adult  AIDS Dementia Complex/BLOOD/*CEREBROSPINAL FLUID/COMPLICATIONS/
       IMMUNOLOGY  Cerebrospinal Fluid Proteins/*ANALYSIS  Comparative Study
       Female  Human  HIV Core Protein p24/BLOOD/*CEREBROSPINAL FLUID
       *HIV-1/IMMUNOLOGY  IgG/BIOSYNTHESIS/*CEREBROSPINAL FLUID  Male  Middle
       Age  Risk Factors  Severity of Illness Index  Substance Abuse,
       Intravenous/COMPLICATIONS  Support, Non-U.S. Gov't  Support, U.S. Gov't,
       Non-P.H.S.  Support, U.S. Gov't, P.H.S.  Syphilis/COMPLICATIONS  T4
       Lymphocytes  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).